Outward transcutaneous chemical migration: Implications for diagnostics and dosimetry

Carl C. Peck*, Dale P. Conner, Brenda J. Bolden, Ramona G. Almirez, Thomas E. Kingsley, Leroy D. Mell, M. Gail Murphy, Vincent E. Hill, Laura M. Rowland, David Ezra, Terease E. Kwiatkowski, Charles R. Bradley, Maged Abdel-Rahim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Chemical substances migrate outwards from within the body to the skin surface by diffusion from cutaneous capillaries across the epidermis. Heretofore, study of transepidermal chemical emissions have been restricted to substances which are in the vapor phase at skin surface temperature. We have investigated outward transcutaneous chemical migration of nongaseous chemicals by devising an occlusive transcutaneous chemical collection system, consisting of a tape-encased plug of gelled saline in which activated carbon is dispersed. Investigations of nine chemicals in ‘fuzzy’ rats, rhesus monkeys, and man provide data which are consistent with a general theory of outward transcutaneous chemical migration. This noninvasive continuous transcutaneous sampling technique provides a new method for investigating skin permeability in vivo and may provide a basis for convenient diagnosis and monitoring of chemical exposure.

Original languageEnglish
Pages (from-to)14-23
Number of pages10
JournalSkin Pharmacology and Physiology
Issue number1
StatePublished - 1988
Externally publishedYes


  • Diffusion
  • Dosimetry
  • Outward transcutaneous chemical migration
  • Permeability coefficient, noninvasive, in vivo
  • Reverse transdermal drug delivery


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