TY - JOUR
T1 - Outflow resistance of enucleated human eyes at two different perfusion pressures and different extents of trabeculotomy
AU - Rosenquist, Robert
AU - Epstein, David
AU - Melamed, Shlomo
AU - Johnson, Mark
AU - Grant, W. Morton
N1 - Funding Information:
ACKNOWLEDGEMENT This study was supported by a grant from the National Eye Institute R01 EY01894 and R01 EY05503 and by the National Glaucoma Research Program, part of the American Health Assistance Foundation.
PY - 1989
Y1 - 1989
N2 - Aqueous outflow resistance of enucleated human eyes was measured at 7 and 25 mm Hg before and after partial and complete (12 clock hours) internal trabeculotomy. Following complete trabeculotomy, 71% of the resistance was eliminated at 25 mm Hg while only 49% was eliminated at 7 mm Hg. In contrast to published findings in eyes with intact trabecular meshwork where the resistance increased with increasing IOP (1), following complete trabeculotomy, the resistance decreased 2% per mm Hg with increasing IOP. Experiments with trabeculotomy limited to part of the circumference showed that a one hour trabeculotomy produced 41% (25 mm Hg) to 60% (7 mm Hg) of the effect of a twelve hour trabeculotomy. The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.
AB - Aqueous outflow resistance of enucleated human eyes was measured at 7 and 25 mm Hg before and after partial and complete (12 clock hours) internal trabeculotomy. Following complete trabeculotomy, 71% of the resistance was eliminated at 25 mm Hg while only 49% was eliminated at 7 mm Hg. In contrast to published findings in eyes with intact trabecular meshwork where the resistance increased with increasing IOP (1), following complete trabeculotomy, the resistance decreased 2% per mm Hg with increasing IOP. Experiments with trabeculotomy limited to part of the circumference showed that a one hour trabeculotomy produced 41% (25 mm Hg) to 60% (7 mm Hg) of the effect of a twelve hour trabeculotomy. The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.
UR - http://www.scopus.com/inward/record.url?scp=0024952760&partnerID=8YFLogxK
U2 - 10.3109/02713688909013902
DO - 10.3109/02713688909013902
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AN - SCOPUS:0024952760
SN - 0271-3683
VL - 8
SP - 1233
EP - 1240
JO - Current Eye Research
JF - Current Eye Research
IS - 12
ER -