Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation

Mark Kheifets*, Filippo Angelini, Fabrizio D’Ascenzo, Stefano Pidello, Haya Engelstein, Pier Paolo Bocchino, Paolo Boretto, Simone Frea, Amos Levi, Hana Vaknin-Assa, Mordehay Vaturi, Yaron Shapira, Ran Kornowski, Leor Perl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Current guidelines support the use of transcatheter edge-to-edge repair (TEER) for patients with both primary and secondary mitral regurgitation. We aimed to compare the prognoses of TEER in degenerative mitral regurgitation (DMR) vs. functional mitral regurgitation (FMR). A total of 208 consecutive patients who underwent TEER over a ten-year period were analyzed. Primary endpoints included rates of all-cause death and major adverse cardiac events (MACE: composite of all-cause death, hospitalizations for heart failure, mitral valve surgery, or TEER re-intervention). A total of 148 (71%) patients were identified with FMR, while 60 (29%) were identified with DMR. Patients in the FMR group were younger (77.2 ± 8.4 vs. 80.2 ± 7.2, p = 0.02), suffered more frequently from coronary artery disease (54.1% vs. 10.0%, p = 0.02), and atrial fibrillation/flutter (70.9% vs. 38.3%, p = 0.02). Rates of 1-year death (21.6% vs. 10.0%, p = 0.03) and MACE (41.2% vs. 21.7%, p = 0.02) were higher for the FMR group, as compared to the DMR group. After correcting for variables, FMR independently predicted rates of MACE (HR-1.78, 95% CI 1.23–2.48, p = 0.04) and had a non-significant effect on one-year mortality (HR-1.67, 95%CI 0.98–3.74, p = 0.07). In our experience, worse overall 1-year composite MACE outcomes were observed after TEER in patients with FMR as compared to patients with DMR.

Original languageEnglish
Article number6010
JournalJournal of Clinical Medicine
Issue number20
StatePublished - Oct 2022


  • degenerative mitral regurgitation (DMR)
  • functional mitral regurgitation (FMR)
  • transcatheter edge-to-edge repair (TEER)


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