Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital

David P. Goldstein; Gideon Y. Bachar; Jane Lea; Mark G. Shrime; Rajan S. Patel; Patrick J. Gullane; Dale H. Brown; Ralph W. Gilbert; John Kim; Jonathan Waldron; Bayardo Perez-Ordonez; Aileen M. Davis; Lu Cheng; Wei Xu; Jonathan C. Irish

doi:10.1002/hed.23001

Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital

David P. Goldstein^*, Gideon Y. Bachar, Jane Lea, Mark G. Shrime, Rajan S. Patel, Patrick J. Gullane, Dale H. Brown, Ralph W. Gilbert, John Kim, Jonathan Waldron, Bayardo Perez-Ordonez, Aileen M. Davis, Lu Cheng, Wei Xu, Jonathan C. Irish

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. Methods We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis. Results Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. Conclusion Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

Original language	English
Pages (from-to)	632-641
Number of pages	10
Journal	Head and Neck
Volume	35
Issue number	5
DOIs	https://doi.org/10.1002/hed.23001
State	Published - May 2013
Externally published	Yes

Keywords

oral cancer
prognosis
squamous cell carcinoma
tongue cancer
treatment outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.23001

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Goldstein, D. P., Bachar, G. Y., Lea, J., Shrime, M. G., Patel, R. S., Gullane, P. J., Brown, D. H., Gilbert, R. W., Kim, J., Waldron, J., Perez-Ordonez, B., Davis, A. M., Cheng, L., Xu, W., & Irish, J. C. (2013). Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital. Head and Neck, 35(5), 632-641. https://doi.org/10.1002/hed.23001

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abstract = "Background The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. Methods We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis. Results Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. Conclusion Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival. {\textcopyright} 2012 Wiley Periodicals, Inc. Head Neck, 2013",

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author = "Goldstein, {David P.} and Bachar, {Gideon Y.} and Jane Lea and Shrime, {Mark G.} and Patel, {Rajan S.} and Gullane, {Patrick J.} and Brown, {Dale H.} and Gilbert, {Ralph W.} and John Kim and Jonathan Waldron and Bayardo Perez-Ordonez and Davis, {Aileen M.} and Lu Cheng and Wei Xu and Irish, {Jonathan C.}",

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AU - Patel, Rajan S.

AU - Gullane, Patrick J.

AU - Brown, Dale H.

AU - Gilbert, Ralph W.

AU - Kim, John

AU - Waldron, Jonathan

AU - Perez-Ordonez, Bayardo

AU - Davis, Aileen M.

AU - Cheng, Lu

AU - Xu, Wei

AU - Irish, Jonathan C.

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N2 - Background The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. Methods We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis. Results Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. Conclusion Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

AB - Background The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. Methods We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis. Results Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. Conclusion Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital

Abstract

Keywords

UN SDGs

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