Outcome of patients with prior coronary bypass surgery admitted with an acute coronary syndrome

Ilan Marcuschamer, Oren Zusman, Z. Iakobishvili, Abid R. Assali, Hanah Vaknin-Assa, Ilan Goldenberg, Tal Cohen, Nir Shlomo, Ran Kornowski, Alon Eisen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background Patients with prior coronary artery bypass graft surgery (CABG) are at increased risk for recurrent cardiovascular ischaemic events. Advances in management have improved prognosis of patients with acute coronary syndrome (ACS), yet it is not known whether similar trends exist in patients with prior CABG. Aim Examine temporal trends in the prevalence, treatment and clinical outcomes of patients with prior CABG admitted with ACS. Methods Time-dependent analysis of patients with or without prior CABG admitted with an ACS who enrolled in the ACS Israeli Surveys between 2000 and 2016. Surveys were divided into early (2000–2008) and late (2010–2016) time periods. Outcomes included 30 days major adverse cardiac events (30d MACE) (death, myocardial infarction, stroke, unstable angina, stent thrombosis, urgent revascularisation) and 1-year mortality. Results Among 15 152 patients with ACS, 1506 (9.9%) had a prior CABG. Patients with prior CABG were older (69 vs 63 years), had more comorbidities and presented more with non-ST elevation-ACS (82% vs 51%). Between time periods, utilisation of antiplatelets, statins and percutaneous interventions significantly increased in both groups (p<0.001 for each). The rate of 30d MACE decreased in patients with (19.1%–12.4%, p=0.001) and without (17.4%–9.5%, p<0.001) prior CABG. However, 1-year mortality decreased only in patients without prior CABG (10.5% vs 7.4%, p<0.001) and remained unchanged in patients with prior CABG. Results were consistent after propensity matching. Conclusions Despite an improvement in the management and prognosis of patients with ACS in the last decade, the rate of 1-year mortality of patients with prior CABG admitted with an ACS remained unchanged.

Original languageEnglish
Pages (from-to)1820-1825
Number of pages6
JournalHeart
Volume107
Issue number22
DOIs
StatePublished - Nov 2021

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