Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study

Ziv Gil; Snehal G. Patel; Giulio Cantu; Dan M. Fliss; Luiz P. Kowalski; Bhuvanesh Singh; Carl Snyderman; Dennis H. Kraus; Jatin P. Shah; Patrick G. Bridger; Anthony D. Cheesman; Paul Donald; Patrick Gullane; Ivo Janecka; Shin Etsu Kamata; Paul A. Levine; Luiz R. Medina; Sultan Pradhan; Victor Schramm; William I. Wei

doi:10.1002/hed.20958

Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study

Ziv Gil, Snehal G. Patel, Giulio Cantu, Dan M. Fliss, Luiz P. Kowalski, Bhuvanesh Singh, Carl Snyderman, Dennis H. Kraus, Jatin P. Shah, Patrick G. Bridger, Anthony D. Cheesman, Paul Donald, Patrick Gullane, Ivo Janecka, Shin Etsu Kamata, Paul A. Levine, Luiz R. Medina, Sultan Pradhan, Victor Schramm, William I. Wei

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Research output: Contribution to journal › Article › peer-review

Abstract

Background. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population.

Original language	English
Pages (from-to)	308-317
Number of pages	10
Journal	Head and Neck
Volume	31
Issue number	3
DOIs	https://doi.org/10.1002/hed.20958
State	Published - Mar 2009

Keywords

Cancer
Children
Cranial base
Malignant tumors
Pediatric tumors
Sarcomas
Skull base

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.20958

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Gil, Z., Patel, S. G., Cantu, G., Fliss, D. M., Kowalski, L. P., Singh, B., Snyderman, C., Kraus, D. H., Shah, J. P., Bridger, P. G., Cheesman, A. D., Donald, P., Gullane, P., Janecka, I., Kamata, S. E., Levine, P. A., Medina, L. R., Pradhan, S., Schramm, V., & Wei, W. I. (2009). Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study. Head and Neck, 31(3), 308-317. https://doi.org/10.1002/hed.20958

@article{8d53da4c02614a9f93246b662d43bd5f,

title = "Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study",

abstract = "Background. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population.",

keywords = "Cancer, Children, Cranial base, Malignant tumors, Pediatric tumors, Sarcomas, Skull base",

author = "Ziv Gil and Patel, {Snehal G.} and Giulio Cantu and Fliss, {Dan M.} and Kowalski, {Luiz P.} and Bhuvanesh Singh and Carl Snyderman and Kraus, {Dennis H.} and Shah, {Jatin P.} and Bridger, {Patrick G.} and Cheesman, {Anthony D.} and Paul Donald and Patrick Gullane and Ivo Janecka and Kamata, {Shin Etsu} and Levine, {Paul A.} and Medina, {Luiz R.} and Sultan Pradhan and Victor Schramm and Wei, {William I.}",

year = "2009",

month = mar,

doi = "10.1002/hed.20958",

language = "אנגלית",

volume = "31",

pages = "308--317",

journal = "Head and Neck",

issn = "1043-3074",

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Gil, Z, Patel, SG, Cantu, G, Fliss, DM, Kowalski, LP, Singh, B, Snyderman, C, Kraus, DH, Shah, JP, Bridger, PG, Cheesman, AD, Donald, P, Gullane, P, Janecka, I, Kamata, SE, Levine, PA, Medina, LR, Pradhan, S, Schramm, V & Wei, WI 2009, 'Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study', Head and Neck, vol. 31, no. 3, pp. 308-317. https://doi.org/10.1002/hed.20958

TY - JOUR

T1 - Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base

T2 - An international collaborative study

AU - Gil, Ziv

AU - Patel, Snehal G.

AU - Cantu, Giulio

AU - Fliss, Dan M.

AU - Kowalski, Luiz P.

AU - Singh, Bhuvanesh

AU - Snyderman, Carl

AU - Kraus, Dennis H.

AU - Shah, Jatin P.

AU - Bridger, Patrick G.

AU - Cheesman, Anthony D.

AU - Donald, Paul

AU - Gullane, Patrick

AU - Janecka, Ivo

AU - Kamata, Shin Etsu

AU - Levine, Paul A.

AU - Medina, Luiz R.

AU - Pradhan, Sultan

AU - Schramm, Victor

AU - Wei, William I.

PY - 2009/3

Y1 - 2009/3

N2 - Background. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population.

AB - Background. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population.

KW - Cancer

KW - Children

KW - Cranial base

KW - Malignant tumors

KW - Pediatric tumors

KW - Sarcomas

KW - Skull base

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U2 - 10.1002/hed.20958

DO - 10.1002/hed.20958

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C2 - 19073003

AN - SCOPUS:62249202085

VL - 31

SP - 308

EP - 317

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 3

ER -

Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study

Abstract

Keywords

UN SDGs

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