Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections

D. Ben-David*, R. Kordevani, N. Keller, I. Tal, A. Marzel, O. Gal-Mor, Y. Maor, G. Rahav

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the impact of carbapenem-resistant K. pneumoniae bloodstream infections on mortality. During the study period 42, 68 and 120 patients were identified with carbapenem-resistant, extended-spectrum β-lactamase producers (ESBL) and susceptible K. pneumoniae bloodstream infections, respectively. Patients with carbapenem-resistant K. pneumoniae had higher rates of prior antimicrobial exposure, other nosocomial infections, and use of invasive devices. Infection-related mortality was 48% for carbapenem-resistant, 22% for ESBL producers and 17% for susceptible K. pneumoniae. Independent risk factors for infection-related mortality were Pitt bacteraemia score, Charlson score and carbapenem resistance.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalClinical Microbiology and Infection
Volume18
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Bloodstream infection
  • Carbapenem resistance
  • Klebsiella pneumoniae
  • Outcome

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