TY - JOUR
T1 - Outcome of Benign Acute Childhood Myositis
T2 - The Experience of 2 Large Tertiary Care Pediatric Hospitals
AU - Rosenberg, Tom
AU - Heitner, Shmuel
AU - Scolnik, Dennis
AU - Levin Ben-Adiva, Einav
AU - Rimon, Ayelet
AU - Glatstein, Miguel
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Objective The aims of the study were to determine the evolution of benign acute childhood myositis in children and to assess the relationship between creatine phosphokinase (CPK) values and myoglobinuria. Study design A retrospective study of patients with benign acute childhood myositis seen in 2 tertiary care university-affiliated pediatric hospitals during overlapping 4-year periods. Methods Demographic data, historical details, clinical, and laboratory results were extracted from the charts of children younger than 16 years with a CPK greater than 3 times normal. Complications, treatments, and outcomes were recorded. Results Fifty-four children were included, 43 (80%) were male, and mean age was 7.3 years (median [range], 6 [3-16] years), none showed abnormal neurological findings, manifested hematuria, or developed renal failure. Mean CPK level at presentation was 1872 IU/L (range, 511-8086 IU/L). None developed renal failure, and there were no adverse outcomes on follow-up. Conclusions Acute childhood myositis is a predominantly benign disease. Neurological examination is usually normal and rhabdomyolysis is rare. Although severe pathological comorbid conditions must be excluded, a complete history and examination, coupled with simple blood and urine tests, can help minimize unnecessary diagnostic investigations.
AB - Objective The aims of the study were to determine the evolution of benign acute childhood myositis in children and to assess the relationship between creatine phosphokinase (CPK) values and myoglobinuria. Study design A retrospective study of patients with benign acute childhood myositis seen in 2 tertiary care university-affiliated pediatric hospitals during overlapping 4-year periods. Methods Demographic data, historical details, clinical, and laboratory results were extracted from the charts of children younger than 16 years with a CPK greater than 3 times normal. Complications, treatments, and outcomes were recorded. Results Fifty-four children were included, 43 (80%) were male, and mean age was 7.3 years (median [range], 6 [3-16] years), none showed abnormal neurological findings, manifested hematuria, or developed renal failure. Mean CPK level at presentation was 1872 IU/L (range, 511-8086 IU/L). None developed renal failure, and there were no adverse outcomes on follow-up. Conclusions Acute childhood myositis is a predominantly benign disease. Neurological examination is usually normal and rhabdomyolysis is rare. Although severe pathological comorbid conditions must be excluded, a complete history and examination, coupled with simple blood and urine tests, can help minimize unnecessary diagnostic investigations.
KW - Creatine phosphokinase
KW - acute renal failure
KW - benign acute childhood myositis
KW - hematuria
KW - rhabdomyolysis
UR - http://www.scopus.com/inward/record.url?scp=84983329183&partnerID=8YFLogxK
U2 - 10.1097/PEC.0000000000000830
DO - 10.1097/PEC.0000000000000830
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C2 - 29851916
AN - SCOPUS:84983329183
SN - 0749-5161
VL - 34
SP - 400
EP - 402
JO - Pediatric Emergency Care
JF - Pediatric Emergency Care
IS - 6
ER -