Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: A survey on behalf of the ALWP of the EBMT

P. Chevallier*, M. Labopin, A. Nagler, P. Ljungman, L. F. Verdonck, L. Volin, A. R. Zander, J. Finke, G. Socie, C. Cordonnier, J. L. Harousseau, M. Mohty, V. Rocha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this multicenter retrospective analysis was to carry out a survey of overall outcomes after allo-hematopoietic SCT of AML patients harboring trisomy 8 (+8) as the sole chromosomal abnormality or associated with other abnormalities. We have identified 182 de novo AML patients who underwent allo-hematopoietic SCT between 1990 and 2007 exhibiting isolated +8 (n = 136) or +8 (n = 46) associated with other favorable (n = 8), intermediate (n = 30), high-risk (n = 7) or unknown (n = 1) cytogenetic abnormalities reported to the European Group of Blood and Marrow Transplantation (EBMT). With a median follow-up of 48 months, 5-year non-relapse mortality, relapse rate, leukemia-free survival and OS were 25, 30, 45 and 47%, respectively. In a multivariate analysis, leukemia-free survival rate was improved when patients were female and transplanted in CR with an HLA-identical sibling donor. Five-year leukemia-free survival was 41, 88, 57 and 21% in patients bearing isolated +8 or +8 and other cytogenetic abnormalities of good, intermediate or poor-risk, respectively. Our retrospective data show that allo-hematopoietic SCT is an effective treatment for AML patients harboring +8. The accompanying cytogenetic abnormality to +8 seems to influence outcomes of these patients.

Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalBone Marrow Transplantation
Volume44
Issue number9
DOIs
StatePublished - 2009

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