Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: A survey on behalf of the ALWP of the EBMT

P. Chevallier, M. Labopin, A. Nagler, P. Ljungman, L. F. Verdonck, L. Volin, A. R. Zander, J. Finke, G. Socie, C. Cordonnier, J. L. Harousseau, M. Mohty, V. Rocha

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this multicenter retrospective analysis was to carry out a survey of overall outcomes after allo-hematopoietic SCT of AML patients harboring trisomy 8 (+8) as the sole chromosomal abnormality or associated with other abnormalities. We have identified 182 de novo AML patients who underwent allo-hematopoietic SCT between 1990 and 2007 exhibiting isolated +8 (n = 136) or +8 (n = 46) associated with other favorable (n = 8), intermediate (n = 30), high-risk (n = 7) or unknown (n = 1) cytogenetic abnormalities reported to the European Group of Blood and Marrow Transplantation (EBMT). With a median follow-up of 48 months, 5-year non-relapse mortality, relapse rate, leukemia-free survival and OS were 25, 30, 45 and 47%, respectively. In a multivariate analysis, leukemia-free survival rate was improved when patients were female and transplanted in CR with an HLA-identical sibling donor. Five-year leukemia-free survival was 41, 88, 57 and 21% in patients bearing isolated +8 or +8 and other cytogenetic abnormalities of good, intermediate or poor-risk, respectively. Our retrospective data show that allo-hematopoietic SCT is an effective treatment for AML patients harboring +8. The accompanying cytogenetic abnormality to +8 seems to influence outcomes of these patients.

Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalBone Marrow Transplantation
Volume44
Issue number9
DOIs
StatePublished - 2009

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