TY - JOUR
T1 - Outan
T2 - An On-Head System for Driving μlED Arrays Implanted in Freely Moving Mice
AU - Tarnavsky Eitan, Alexander
AU - Someck, Shirly
AU - Zajac, Mario
AU - Socher, Eran
AU - Stark, Eran
N1 - Publisher Copyright:
© 2007-2012 IEEE.
PY - 2021/4
Y1 - 2021/4
N2 - In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and μLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary current sources. We designed and fabricated a current source chip and integrated it into a headstage PCB that weighs 1.37 g. The proposed system provides 10-bit resolution current control for 32 channels, driving μLEDs with up to 4.6 V and sourcing up to 0.9 mA at a refresh rate of 5 kHz per channel. When calibrated against a μLED probe, the system allows linear control of light output power, up to 10 μW per μLED. To demonstrate the capabilities of the system, synthetic sequences of neural spiking activity were produced by driving multiple μLEDs implanted in the hippocampal CA1 area of a freely moving mouse. The high spatial, temporal, and amplitude resolution of the system provides a rich variety of stimulation patterns. Combined with commercially available sampling headstages, the system provides an easy to use back-end, fully utilizing the bi-directional potential of integrated opto-electronic arrays.
AB - In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and μLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary current sources. We designed and fabricated a current source chip and integrated it into a headstage PCB that weighs 1.37 g. The proposed system provides 10-bit resolution current control for 32 channels, driving μLEDs with up to 4.6 V and sourcing up to 0.9 mA at a refresh rate of 5 kHz per channel. When calibrated against a μLED probe, the system allows linear control of light output power, up to 10 μW per μLED. To demonstrate the capabilities of the system, synthetic sequences of neural spiking activity were produced by driving multiple μLEDs implanted in the hippocampal CA1 area of a freely moving mouse. The high spatial, temporal, and amplitude resolution of the system provides a rich variety of stimulation patterns. Combined with commercially available sampling headstages, the system provides an easy to use back-end, fully utilizing the bi-directional potential of integrated opto-electronic arrays.
KW - Application specific integrated circuits
KW - In vivo
KW - electrophysiology
KW - mixed analog digital integrated circuits
KW - neural engineering
KW - neuroscience
UR - http://www.scopus.com/inward/record.url?scp=85103279860&partnerID=8YFLogxK
U2 - 10.1109/TBCAS.2021.3068556
DO - 10.1109/TBCAS.2021.3068556
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C2 - 33760740
AN - SCOPUS:85103279860
SN - 1932-4545
VL - 15
SP - 303
EP - 313
JO - IEEE Transactions on Biomedical Circuits and Systems
JF - IEEE Transactions on Biomedical Circuits and Systems
IS - 2
M1 - 9385944
ER -