O2 Uptake in hyperthyroidism during constant work rate and incremental exercise

I. Ben-Dov, K. E. Sietsema, K. Wasserman

Research output: Contribution to journalArticlepeer-review


To investigate the effect of hyperthyroidism on the pattern and time course of O2 uptake ( {Mathematical expression}O2) following the transition from rest to exercise, six patients and six healthy subjects performed cycle exercise at an average work rate (WR) of 18 and 20 W respectively. Cardiorespiratory variables were measured breath-by-breath. The patients also performed a progressively increasing WR test (1-min increments) to the limit of tolerance. Two patients repeated the studies when euthyroid. Resting and exercise steady-state (SS) {Mathematical expression}O2 (ml·kg-1·min-1) were higher in the patients than control (5.8, SD 0.9 vs 4.0, SD 0.3 and 12.1, SD 1.5 vs 10.2, SD 1.0 respectively). The increase in {Mathematical expression}O2 during the first 20 s exercise (phase I) was lower in the patients (mean 89 ml·min-, SD 30) compared to the control (265 ml·min-1, SD 90), while the difference in half time of the subsequent (phase 11) increase to the SS {Mathematical expression}O2 (patient 26 s, SD 8; controls 17 s, SD 8) were not significant (P = 0.06). The OZ cost per WR increment (Δ {Mathematical expression}O2/ΔWR) in ml·min-1·-1, measured during the incremental period (mean 10.9; range 8.3-12.2), was always within two standard deviations of the normal value (10.3, SD 1). In the two patients who repeated the tests, both the increment of {Mathematical expression}O2 from rest to SS during constant WR exercise and the Δ {Mathematical expression}O2/ΔWRs during the progressive exercise were higher in the hyperthyroid state than during the euthyroid state. While both resting and exercise {Mathematical expression}O2 are increased in the hyperthyroid patients, the O2 cost of a given increment of WR is within the normal range. However, a small reduction in the {Mathematical expression}O2 requirement to perform exercise following treatment of the hyperthyroid state suggests a subtle change O2 cost of muscle work in this disease.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Issue number4
StatePublished - Jul 1991
Externally publishedYes


  • Hypermetabolic state
  • O Uptake kinetics
  • Pulmonary gas exchange
  • Work efficiency


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