O2 consumption in the in-vitro fetal side human placenta

Haya Mover-Lev; David Dreval; Haim Zakut; Amos Ar

doi:10.1016/S0034-5687(96)00078-3

O₂ consumption in the in-vitro fetal side human placenta

Haya Mover-Lev^*
, David Dreval
, Haim Zakut
, Amos Ar

^*Corresponding author for this work

School of Zoology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The relative dependence of placental O₂ consumption (Ṁ(O₂),) on O₂ supply (SupO₂) parameters, and the fraction of aerobic O₂ utilization, was studied by in-vitro perfusion of the fetal side of term human placental lobes. Placental Ṁ(O₂), was a function of the combined effect of SupO₂ parameters (P(O₂), perfusate flow rate, perfusate effective O₂ solubility) and not of each separately. At SupO₂ greater than 800 μl/(min · lobe), Ṁ(O₂) saturated at 260 μl/min · lobe). No accumulation of O₂ debt could be detected even after 2 h anoxia. Adding CN^- or CO to perfusate did not abolish Ṁ(O₂), and a residual Ṁ(O₂) of 31-37% of control Ṁ(O₂) was measured. In its Ṁ(O₂), the placenta is a typical conformer tissue. This conformity enables conservation of O₂ transfer to the embryo even when placental SupO₂ is radically reduced. Only about 60-70% of placental Ṁ(O₂) is utilized in the aerobic respiratory pathway, while about 30-40% of the oxygen is used in other pathways.

Original language	English
Pages (from-to)	199-208
Number of pages	10
Journal	Respiration Physiology
Volume	106
Issue number	2
DOIs	https://doi.org/10.1016/S0034-5687(96)00078-3
State	Published - Nov 1996

Keywords

Development, placenta
Mammals, humans
Metabolism
O consumption
Placenta, O consumption

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10.1016/S0034-5687(96)00078-3

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title = "O2 consumption in the in-vitro fetal side human placenta",

abstract = "The relative dependence of placental O2 consumption (Ṁ(O2),) on O2 supply (SupO2) parameters, and the fraction of aerobic O2 utilization, was studied by in-vitro perfusion of the fetal side of term human placental lobes. Placental Ṁ(O2), was a function of the combined effect of SupO2 parameters (P(O2), perfusate flow rate, perfusate effective O2 solubility) and not of each separately. At SupO2 greater than 800 μl/(min · lobe), Ṁ(O2) saturated at 260 μl/min · lobe). No accumulation of O2 debt could be detected even after 2 h anoxia. Adding CN- or CO to perfusate did not abolish Ṁ(O2), and a residual Ṁ(O2) of 31-37\% of control Ṁ(O2) was measured. In its Ṁ(O2), the placenta is a typical conformer tissue. This conformity enables conservation of O2 transfer to the embryo even when placental SupO2 is radically reduced. Only about 60-70\% of placental Ṁ(O2) is utilized in the aerobic respiratory pathway, while about 30-40\% of the oxygen is used in other pathways.",

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author = "Haya Mover-Lev and David Dreval and Haim Zakut and Amos Ar",

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AU - Dreval, David

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AU - Ar, Amos

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N2 - The relative dependence of placental O2 consumption (Ṁ(O2),) on O2 supply (SupO2) parameters, and the fraction of aerobic O2 utilization, was studied by in-vitro perfusion of the fetal side of term human placental lobes. Placental Ṁ(O2), was a function of the combined effect of SupO2 parameters (P(O2), perfusate flow rate, perfusate effective O2 solubility) and not of each separately. At SupO2 greater than 800 μl/(min · lobe), Ṁ(O2) saturated at 260 μl/min · lobe). No accumulation of O2 debt could be detected even after 2 h anoxia. Adding CN- or CO to perfusate did not abolish Ṁ(O2), and a residual Ṁ(O2) of 31-37% of control Ṁ(O2) was measured. In its Ṁ(O2), the placenta is a typical conformer tissue. This conformity enables conservation of O2 transfer to the embryo even when placental SupO2 is radically reduced. Only about 60-70% of placental Ṁ(O2) is utilized in the aerobic respiratory pathway, while about 30-40% of the oxygen is used in other pathways.

AB - The relative dependence of placental O2 consumption (Ṁ(O2),) on O2 supply (SupO2) parameters, and the fraction of aerobic O2 utilization, was studied by in-vitro perfusion of the fetal side of term human placental lobes. Placental Ṁ(O2), was a function of the combined effect of SupO2 parameters (P(O2), perfusate flow rate, perfusate effective O2 solubility) and not of each separately. At SupO2 greater than 800 μl/(min · lobe), Ṁ(O2) saturated at 260 μl/min · lobe). No accumulation of O2 debt could be detected even after 2 h anoxia. Adding CN- or CO to perfusate did not abolish Ṁ(O2), and a residual Ṁ(O2) of 31-37% of control Ṁ(O2) was measured. In its Ṁ(O2), the placenta is a typical conformer tissue. This conformity enables conservation of O2 transfer to the embryo even when placental SupO2 is radically reduced. Only about 60-70% of placental Ṁ(O2) is utilized in the aerobic respiratory pathway, while about 30-40% of the oxygen is used in other pathways.

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O₂ consumption in the in-vitro fetal side human placenta

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