TY - JOUR
T1 - O2 consumption in the in-vitro fetal side human placenta
AU - Mover-Lev, Haya
AU - Dreval, David
AU - Zakut, Haim
AU - Ar, Amos
PY - 1996/11
Y1 - 1996/11
N2 - The relative dependence of placental O2 consumption (Ṁ(O2),) on O2 supply (SupO2) parameters, and the fraction of aerobic O2 utilization, was studied by in-vitro perfusion of the fetal side of term human placental lobes. Placental Ṁ(O2), was a function of the combined effect of SupO2 parameters (P(O2), perfusate flow rate, perfusate effective O2 solubility) and not of each separately. At SupO2 greater than 800 μl/(min · lobe), Ṁ(O2) saturated at 260 μl/min · lobe). No accumulation of O2 debt could be detected even after 2 h anoxia. Adding CN- or CO to perfusate did not abolish Ṁ(O2), and a residual Ṁ(O2) of 31-37% of control Ṁ(O2) was measured. In its Ṁ(O2), the placenta is a typical conformer tissue. This conformity enables conservation of O2 transfer to the embryo even when placental SupO2 is radically reduced. Only about 60-70% of placental Ṁ(O2) is utilized in the aerobic respiratory pathway, while about 30-40% of the oxygen is used in other pathways.
AB - The relative dependence of placental O2 consumption (Ṁ(O2),) on O2 supply (SupO2) parameters, and the fraction of aerobic O2 utilization, was studied by in-vitro perfusion of the fetal side of term human placental lobes. Placental Ṁ(O2), was a function of the combined effect of SupO2 parameters (P(O2), perfusate flow rate, perfusate effective O2 solubility) and not of each separately. At SupO2 greater than 800 μl/(min · lobe), Ṁ(O2) saturated at 260 μl/min · lobe). No accumulation of O2 debt could be detected even after 2 h anoxia. Adding CN- or CO to perfusate did not abolish Ṁ(O2), and a residual Ṁ(O2) of 31-37% of control Ṁ(O2) was measured. In its Ṁ(O2), the placenta is a typical conformer tissue. This conformity enables conservation of O2 transfer to the embryo even when placental SupO2 is radically reduced. Only about 60-70% of placental Ṁ(O2) is utilized in the aerobic respiratory pathway, while about 30-40% of the oxygen is used in other pathways.
KW - Development, placenta
KW - Mammals, humans
KW - Metabolism
KW - O consumption
KW - Placenta, O consumption
UR - http://www.scopus.com/inward/record.url?scp=0030273890&partnerID=8YFLogxK
U2 - 10.1016/S0034-5687(96)00078-3
DO - 10.1016/S0034-5687(96)00078-3
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AN - SCOPUS:0030273890
SN - 0034-5687
VL - 106
SP - 199
EP - 208
JO - Respiration Physiology
JF - Respiration Physiology
IS - 2
ER -