Osteosarcoma over the age of forty

Rob J. Grimer*, S. R. Cannon, A. M. Taminiau, S. Bielack, B. Kempf-Bielack, R. Windhager, M. Dominkus, G. Saeter, H. Bauer, I. Meller, M. Szendroi, G. Folleras, M. San-Julian, J. Van der Eijken

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The European Musculo Skeletal Oncology Society (EMSOS) has carried out a retrospective review of patients over the age of 40 years with osteosarcoma. 481 patients from 12 centres or multicentric groups were included. 42 patients had osteosarcoma arising in Paget's disease, median survival was 9 months. Patients with axial or metastatic tumours also did badly whilst 41 patients with radiation-induced osteosarcoma had a prognosis paralleling conventional osteosarcoma matched for patient age and site of the tumour. 238 patients had high grade non-metastatic osteosarcoma and had a survival of 46% at 5 years. Older patients had less chemotherapy and fared worse. Osteosarcoma in the elderly is a curable condition and warrants intensive treatment with chemotherapy and surgical resection.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalEuropean Journal of Cancer
Issue number2
StatePublished - Jan 2003
Externally publishedYes


  • Osteosarcoma
  • Paget's sarcoma
  • Radiation-induced sarcoma


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