Osteoblasts release a soluble factor that modulates immunoglobulin secretion by mature B cells

Dafna Benayahu*, Irit Altboum, Dov Zipori, Shlomo Wientroub, Israel Zan-Bar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

An osteogenic member, MBA-15 cell line, from marrow stroma compartment, was examined for its ability to regulate mature lymphoma B cell line functions. The effect of MBA-15 cell secreting factor/s on cell proliferation, immunoglobulin secretion and isotype switch of 29M4.1 IgM+ mature B cell line was examined. The factor causes temporal arrest in cell proliferation, augments immunoglobulin secretion and has no effect on isotype switching. The results revealed a direct effect of the MBA-15 factors on the B cell functions. Factors secreted by other osteoblastic cells (ROS 17/2.8 and MC-3T3-E1) possess the same biological activities. In contrast, factors secreted by an endothelial adipocyte stromal cell line 14F1.1 lack these properties.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume194
Issue number1
DOIs
StatePublished - 15 Jul 1993

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