Origin of Intranuclear Inclusions in Myeloma Cells

M. Djaldetti*, U. H. Lewinski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The mechanism of inclusion of the cytoplasmic dense bodies into the nucleus of myeloma cells was studied by transmission electron microscopy. The findings in different cells suggest that the inclusion of the electron‐dense bodies is a result of an interaction between the nuclear envelope and the endoplasmic reticulum. The ability of the nuclear membrane to form an extension into the cytoplasm and the connection with the cisternae of endoplasmic reticulum enables the movement of the dense bodies towards the nucleus. The proposed mechanism does not support the concept of a simple invagination of the bodies into the nucleus or that they are produced in the nucleus itself.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalScandinavian Journal of Haematology
Volume20
Issue number3
DOIs
StatePublished - Mar 1978

Keywords

  • cell nucleus
  • cytoplasmic dense bodies
  • endoplasmic reticulum
  • myeloma cells
  • transmission electron microscopy

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