TY - JOUR
T1 - Orientation-dependent kinetics of heterogeneous electron transfer for cytochrome c immobilized on gold
T2 - Electrochemical determination and theoretical prediction
AU - Bortolotti, Carlo Augusto
AU - Borsari, Marco
AU - Sola, Marco
AU - Chertkova, Rita
AU - Dolgikh, Dmitry
AU - Kotlyar, Alexander
AU - Facci, Paolo
PY - 2007/8/16
Y1 - 2007/8/16
N2 - A systematic comparison between electron-transfer rate constants measured electrochemically for different cysteine-bearing mutants of cytochrome c chemisorbed on gold surfaces in different orientations has been performed. Experimental data have been correlated with electronic coupling theoretical estimates obtained from two different empirical models for the kinetics of protein electron transfer, the tunneling pathway model and the average packing density model. The results indicate that both models also hold in the case of immobilized redox proteins, outlining their role in the rational design of optimized electron-transfer-based bioinorganic interfaces.
AB - A systematic comparison between electron-transfer rate constants measured electrochemically for different cysteine-bearing mutants of cytochrome c chemisorbed on gold surfaces in different orientations has been performed. Experimental data have been correlated with electronic coupling theoretical estimates obtained from two different empirical models for the kinetics of protein electron transfer, the tunneling pathway model and the average packing density model. The results indicate that both models also hold in the case of immobilized redox proteins, outlining their role in the rational design of optimized electron-transfer-based bioinorganic interfaces.
UR - http://www.scopus.com/inward/record.url?scp=34548213830&partnerID=8YFLogxK
U2 - 10.1021/jp072813g
DO - 10.1021/jp072813g
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AN - SCOPUS:34548213830
SN - 1932-7447
VL - 111
SP - 12100
EP - 12105
JO - Journal of Physical Chemistry C
JF - Journal of Physical Chemistry C
IS - 32
ER -