Organized Toe Maps in Extreme Foot Users

Harriet Dempsey-Jones, Daan B. Wesselink, Jason Friedman, Tamar R. Makin

Research output: Contribution to journalArticlepeer-review

Abstract

Although the fine-grained features of topographic maps in the somatosensory cortex can be shaped by everyday experience, it is unknown whether behavior can support the expression of somatotopic maps where they do not typically occur. Unlike the fingers, represented in all primates, individuated toe maps have only been found in non-human primates. Using 1-mm resolution fMRI, we identify organized toe maps in two individuals born without either upper limb who use their feet to substitute missing hand function and even support their profession as foot artists. We demonstrate that the ordering and structure of the artists’ toe representation mimics typical hand representation. We further reveal “hand-like” features of activity patterns, not only in the foot area but also similarly in the missing hand area. We suggest humans may have an innate capacity for forming additional topographic maps that can be expressed with appropriate experience.

Original languageEnglish
Pages (from-to)2748-2756.e4
JournalCell Reports
Volume28
Issue number11
DOIs
StatePublished - 10 Sep 2019

Keywords

  • adaptive
  • amputees
  • deprivation
  • ecological behavior
  • fMRI
  • hand
  • plasticity
  • reorganization
  • sensorimotor
  • somatotopy

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