TY - JOUR
T1 - Organ Preservation in Rectal Cancer
AU - Yuval, Jonathan B.
AU - Thompson, Hannah M.
AU - Garcia-Aguilar, Julio
N1 - Publisher Copyright:
© 2020, The Society for Surgery of the Alimentary Tract.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - A proportion of patients with rectal cancer who undergo neoadjuvant treatment end up with a complete pathological response. Because these patients have excellent oncological outcomes, many have questioned if surgical treatment in this population constitutes overtreatment. There is growing interest in watch and wait with selective organ preservation for rectal cancer patients. We review the fundamentals and key considerations of this approach including patient selection, available treatment regimens, assessment of response, long-term monitoring of response, and long-term oncological and functional outcomes.
AB - A proportion of patients with rectal cancer who undergo neoadjuvant treatment end up with a complete pathological response. Because these patients have excellent oncological outcomes, many have questioned if surgical treatment in this population constitutes overtreatment. There is growing interest in watch and wait with selective organ preservation for rectal cancer patients. We review the fundamentals and key considerations of this approach including patient selection, available treatment regimens, assessment of response, long-term monitoring of response, and long-term oncological and functional outcomes.
KW - Nonoperative management
KW - Organ preservation
KW - Rectal cancer
KW - Watch-and-wait
UR - http://www.scopus.com/inward/record.url?scp=85083644526&partnerID=8YFLogxK
U2 - 10.1007/s11605-020-04583-w
DO - 10.1007/s11605-020-04583-w
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C2 - 32314234
AN - SCOPUS:85083644526
SN - 1091-255X
VL - 24
SP - 1880
EP - 1888
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 8
ER -
