Orbital Development in Children with Retinoblastoma: An Imaging-Based Study

Purpose: To examine whether children treated for Retinoblastoma (Rb) have impaired orbital development. Methods: A retrospective case series was performed among children with Rb treated at a single medical center from 2004 to 2020. Orbital volumes and measurements were assessed by 3-dimensional image processing software. The main outcome measures were differences in orbital growth between Rb and non-Rb eyes assessed at last follow-up. Results: Among 44 patients included (mean age 16.09 ± 18.01 months), a positive correlation between age and orbital volume was observed only in the uninvolved, healthy eyes (p =.03). In unilateral cases, orbital growth in the horizontal, vertical, and depth planes was smaller on the affected side compared to the healthy eyes (p <.05). Orbits that underwent enucleation showed decreased growth over time compared to those treated conservatively (p =.017). Conclusions: Orbital growth rate is slower in the orbits of children treated for Rb compared to healthy orbits. Enucleation negatively affects orbital growth.