Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis

Ran Yahalom, Noam Yarom, Tali Shani, Ninet Amariglio, Ilana Kaplan, Luba Trakhtenbrot, Abraham Hirshberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP. Methods Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8. Results. Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found. Conclusion High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up.

Original languageEnglish
Pages (from-to)E741-E746
JournalHead and Neck
Volume38
DOIs
StatePublished - 1 Apr 2016

Keywords

  • aneuploidy
  • chromosomal instability
  • oral cancer
  • oral lichen planus

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