Oral ciprofloxacin in the management of chronic suppurative otitis media without cholesteatoma in children: Preliminary experience in 21 children

Ruth Lang, Siven Goshen, Annick Raas-Rothschild, Aryeh Raz, Ophir Dov, Baruch Wolach, Isaac Berger

Research output: Contribution to journalArticlepeer-review

Abstract

The current medical management of children with chronic suppurative otitis media without cholesteatoma unresponsive to local treatmentand oral antibiotics is intravenous antibiotic therapy in the hospital setting. We studied the efficacy and toxicity of oral ciprofloxacin in chronic suppurative otitis media. Twenty-one children received oral ciprofloxacin, 30 mg/kg/ day. Ear discharge was positive for bacteria resistant to other oral medications and susceptible to the quinolones. The mean duration of treatment was 16.7 days. In 18 children suppuration ceased and 3 failed their first course. During a mean follow-up of 15.4 months, 6 children remained free of ear, nose and throat problems. Otorrhea recurred in 12 children. Ear cultures were positive for organisms susceptible to amoxicillin in 5 of them. In 7 cases Pseudomonas aeruginosa was again isolated from otorrhea. Repeated antibiotic therapy was advocated only in 3 (2 responded to ciprofloxacin; 1 failed ciprofloxacin and was cured by ceftazidime). Adverse clinical effects were not observed. Transient neutropenia was observed in 1 child. There was no change in the height percentile. The results of this study show that children with chronic suppurative otitis media without cholesteatoma can be effectively treated with oral ciprofloxacin. This novel approach may prevent hospitalization.

Original languageEnglish
Pages (from-to)925-929
Number of pages5
JournalPediatric Infectious Disease Journal
Volume11
Issue number11
DOIs
StatePublished - Nov 1992

Keywords

  • Chronic suppurative otitis media
  • Ciprofloxacin
  • Pseudomonas

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