Oral anticoagulants in the elderly

Paul Froom; Ehud Miron; Mira Barak

doi:10.1046/j.1365-2141.2003.04110.x

Oral anticoagulants in the elderly

Paul Froom^*, Ehud Miron, Mira Barak

^*Corresponding author for this work

Clalit Health Services

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Over a 1-year period, 34 998 prothrombin time tests were performed on 2379 patients aged 40-89 years with a recommended target International Normalized Ratio (INR) value of 2.5. At least one INR value of ≥5 was found in 507/2379 patients (21.3%). The elderly demonstrated higher maximum and lower minimum INR values, lower warfarin doses, and an increased number of tests performed. After adjustment for these factors, the risk of INR values ≥5 increased with age by 15% every 10years (95% CI 4-28%). We conclude that age is a risk factor for more unstable prothrombin time results.

Original language	English
Pages (from-to)	526-528
Number of pages	3
Journal	British Journal of Haematology
Volume	120
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04110.x
State	Published - Feb 2003
Externally published	Yes

Keywords

Anticoagulation
Control
Elderly
INR
Instability

Access to Document

10.1046/j.1365-2141.2003.04110.x

Cite this

@article{660a7a068fcc4697b2ab0420968424c0,

title = "Oral anticoagulants in the elderly",

abstract = "Over a 1-year period, 34 998 prothrombin time tests were performed on 2379 patients aged 40-89 years with a recommended target International Normalized Ratio (INR) value of 2.5. At least one INR value of ≥5 was found in 507/2379 patients (21.3%). The elderly demonstrated higher maximum and lower minimum INR values, lower warfarin doses, and an increased number of tests performed. After adjustment for these factors, the risk of INR values ≥5 increased with age by 15% every 10years (95% CI 4-28%). We conclude that age is a risk factor for more unstable prothrombin time results.",

keywords = "Anticoagulation, Control, Elderly, INR, Instability",

author = "Paul Froom and Ehud Miron and Mira Barak",

year = "2003",

month = feb,

doi = "10.1046/j.1365-2141.2003.04110.x",

language = "אנגלית",

volume = "120",

pages = "526--528",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Oral anticoagulants in the elderly

AU - Froom, Paul

AU - Miron, Ehud

AU - Barak, Mira

PY - 2003/2

Y1 - 2003/2

N2 - Over a 1-year period, 34 998 prothrombin time tests were performed on 2379 patients aged 40-89 years with a recommended target International Normalized Ratio (INR) value of 2.5. At least one INR value of ≥5 was found in 507/2379 patients (21.3%). The elderly demonstrated higher maximum and lower minimum INR values, lower warfarin doses, and an increased number of tests performed. After adjustment for these factors, the risk of INR values ≥5 increased with age by 15% every 10years (95% CI 4-28%). We conclude that age is a risk factor for more unstable prothrombin time results.

AB - Over a 1-year period, 34 998 prothrombin time tests were performed on 2379 patients aged 40-89 years with a recommended target International Normalized Ratio (INR) value of 2.5. At least one INR value of ≥5 was found in 507/2379 patients (21.3%). The elderly demonstrated higher maximum and lower minimum INR values, lower warfarin doses, and an increased number of tests performed. After adjustment for these factors, the risk of INR values ≥5 increased with age by 15% every 10years (95% CI 4-28%). We conclude that age is a risk factor for more unstable prothrombin time results.

KW - Anticoagulation

KW - Control

KW - Elderly

KW - INR

KW - Instability

UR - http://www.scopus.com/inward/record.url?scp=0037323949&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2003.04110.x

DO - 10.1046/j.1365-2141.2003.04110.x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0037323949

SN - 0007-1048

VL - 120

SP - 526

EP - 528

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 3

ER -

Oral anticoagulants in the elderly

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this