Optical density of subretinal fluid in retinal detachment

Ari Leshno, Adiel Barak, Anat Loewenstein, Amit Weinberg, Meira Neudorfer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


PURPOSE. To investigate the changes over time in optical density (OD) characteristics of subretinal fluid (SRF) in rhegmatogenous retinal detachment (RRD) and their clinical relevance. METHODS. The study included patients with first-onset RRD and no history of intraocular illness who underwent optical coherence tomography (OCT) and whose OCT scans showed sufficient SRF for sampling (08/2013–09/2014). The highest quality B-scan (as graded by the OCT image acquisition software) containing SRF was analyzed. Optical density measurements were obtained using ImageJ. Optical density ratios (ODRs) were calculated as SRF OD divided by vitreous OD. Time from onset of RRD was determined by first signs of visual loss as described in the patient’s anamnesis. Patients were divided into three groups by RRD duration: acute (£ 1 week), subacute (between 1 week and 1 month), and chronic (>1 month). RESULTS. Thirty-five eyes (34 patients) met the inclusion criteria. The ODR measurement was significantly associated with RRD duration. The ODR had a significant (P < 0.0001) association with the 3-month postoperative visual acuity (VA). Vitreous OD did not differ significantly between the three groups. CONCLUSIONS. The increase over time in the ODR of the SRF in RRD might reflect a change in SRF composition and state of the retina. This, together with a significant association between preoperative ODR values and postoperative VA suggest its potential as a biological prognostic marker.

Original languageEnglish
Pages (from-to)5432-5438
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number9
StatePublished - 2015


  • OCT
  • Optical density
  • Retinal detachment
  • Subretinal fluid


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