Optic pathway gliomas in adults

Ben Shofty, Shlomi Constantini*, Felix Bokstein, Zvi Ram, Liat Ben-Sira, Sigal Freedman, Gilad Vainer, Anat Kesler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


BACKGROUND:: Optic pathway gliomas (OPGs) are considered relatively benign pediatric tumors. Adult patients with OPG can be divided into 2 groups: adult patients with tumors diagnosed in childhood and adult patients diagnosed during adulthood. OBJECTIVE:: To characterize the clinical course of adult patients with OPG. METHODS:: We retrospectively collected clinical and imaging data of all adult OPG patients monitored in our medical center between 1990 and 2012. RESULTS:: Twenty-two adult patients were included. Age at diagnosis varied widely (6 months-66 years), as did age at last follow-up (18-74 years). Ten patients were diagnosed at adulthood and 12 in childhood. Of the patients diagnosed at childhood, 6 had radiological progression during childhood, and 3 of those patients suffered visual impairment. From this group, 1 patient had further progression during adulthood accompanied by additional visual decline, and 2 patients had additional visual decline during adulthood despite no signs of progression. Of the 6 patients whose tumors were stable during childhood, all 6 remained stable during adulthood. Of 10 patients diagnosed at adulthood, 6 patients suffered visual deterioration; in 5 of them, a concomitant progression was noted. Two patients were diagnosed with high-grade gliomas. CONCLUSION:: OPGs may be active during childhood or adulthood. Those patients who experienced anatomic activity during childhood are prone to continue experiencing active disease during adulthood. A significant percentage of patients diagnosed with low-grade OPG at adulthood may suffer progression, visual decline, or both. ABBREVIATIONS:: NF1, neurofibromatosis 1OPG, optic pathway gliomas.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
Issue number3
StatePublished - Mar 2014


  • Low-grade glioma
  • NF1
  • Neurofibromatosis
  • OPG
  • Optic pathway gliomas


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