TY - JOUR
T1 - Optic nerve
T2 - Separating compartments based on 23Na TQF spectra and TQF-diffusion anisotropy
AU - Eliav, Uzi
AU - Xu, Xiang
AU - Jerschow, Alexej
AU - Navon, Gil
N1 - Funding Information:
This work was supported by grants from the US–Israel Bi-national Science Foundation No. 2007157 , the Israel Science Foundation No. 1335/07 and the US National Science Foundation (NSF) CHE 0957586. The work was conducted partly in a facility constructed with support from Research Facilities Improvement Grant Number C06 RR-16572-01 from the National Center for Research Resources (NCRR), NIH. X. Xu is grateful for the support from the Margaret and Herman Sokol Fellowship.
PY - 2013/6
Y1 - 2013/6
N2 - We present a triple quantum filtered (TQF) sodium spectroscopy study of an excised bovine optic nerve. By choosing proper experimental parameters, this technique allowed us to independently observe the satellite transitions originating from the various compartments in the tissue. TQF-based diffusion experiments provided further characterization of the compartments in terms of their geometry. As a result, the peak that exhibited the smallest residual quadrupolar splitting, and the largest diffusion anisotropy was assigned to axons. Two other pairs of satellite peaks were assigned to extra-cellular compartments on the basis of either the size of their quadrupolar splitting or the diffusion properties.
AB - We present a triple quantum filtered (TQF) sodium spectroscopy study of an excised bovine optic nerve. By choosing proper experimental parameters, this technique allowed us to independently observe the satellite transitions originating from the various compartments in the tissue. TQF-based diffusion experiments provided further characterization of the compartments in terms of their geometry. As a result, the peak that exhibited the smallest residual quadrupolar splitting, and the largest diffusion anisotropy was assigned to axons. Two other pairs of satellite peaks were assigned to extra-cellular compartments on the basis of either the size of their quadrupolar splitting or the diffusion properties.
KW - Diffusion anisotropy
KW - Na NMR
KW - Optic nerve
KW - Triple quantum filter
UR - http://www.scopus.com/inward/record.url?scp=84875972329&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2013.03.006
DO - 10.1016/j.jmr.2013.03.006
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C2 - 23588155
AN - SCOPUS:84875972329
SN - 1090-7807
VL - 231
SP - 61
EP - 65
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
ER -