Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses

A. Tanay, S. Strober

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of total lymphoid irradiation (TLI) on the primary antibody response to the dinitrophenylated heterologous protein, keyhole limpet hemocyanin (DNP-KLH), in complete Freund's adjuvant (CFA), and to the trinitrophenylated polysaccharide antigen, Brucella abortus (TNP-BA), was studied in BALB/c mice. The antibody response to both antigens was diminished in comparison with nonirradiated mice when antigens were injected within 3 days after TLI. When the mice were immunized 30 days after completion of TLI the antibody response to DNP-KLH in CFA was still diminished, but the antibody response to TNP-BA was enhanced 5- to 10-fold as compared with that of control animals. The opposite effect of TLI on the two antibody responses was also observed in a syngeneic primary adoptive transfer system.

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalJournal of Immunology
Volume132
Issue number2
StatePublished - 1984
Externally publishedYes

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