Opposite effects of endothelin-1 and big-endothelin-(1-39) on renal function in rats

Aaron Hoffman; Ehud Grossman; Harry R. Keiser

doi:10.1016/0014-2999(90)90064-D

Opposite effects of endothelin-1 and big-endothelin-(1-39) on renal function in rats

Aaron Hoffman^*, Ehud Grossman, Harry R. Keiser

^*Corresponding author for this work

Faculty of Medicine

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1.

Original language	English
Pages (from-to)	603-606
Number of pages	4
Journal	European Journal of Pharmacology
Volume	182
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(90)90064-D
State	Published - 17 Jul 1990

Keywords

Endothelin
Renal blood flow
Renal function

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10.1016/0014-2999(90)90064-D

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abstract = "Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1.",

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AU - Keiser, Harry R.

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N2 - Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1.

AB - Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1.

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Opposite effects of endothelin-1 and big-endothelin-(1-39) on renal function in rats

Abstract

Keywords

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