Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels

O. Keren*, M. Gafni, Y. Sarne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Opioids induce dual (inhibitory and excitatory) regulation of depolarization-evoked [3H]dopamine release in SK-N-SH cells through either μ or δ receptors. The potentiation of dopamine release by opioid agonists is mediated by N-type voltage-dependent calcium channels and does not involve G(i)/G(o) proteins. Removal of the excitatory opioid effect by blockade with Ω-conotoxin, an N-channel antagonist, reveals the inhibitiory effect of opioids on release, thus suggesting that both modulatory effects of opioids are exerted in parallel.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalBrain Research
Volume764
Issue number1-2
DOIs
StatePublished - 1 Aug 1997

Keywords

  • Calcium channel
  • Dopamine
  • Neuroblastoma
  • Opioid receptor
  • Pertussis toxin
  • Transmitter release

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