Opiate and non-opiate aspects of morphine induced seizures

Hanan Frenk*, Alexander Liban, Ron Balamuth, Gideon Urca

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The intraperitoneal administration of morphine hydrochloride at doses of 300 mg/kg produced analgesia, catalepsy, and electrographic spiking in rats that developed into electrographic seizure patterns after approximately 2.5 h. Whereas naltrexone (12 mg/kg) reversed analgesia and catalepsy, and diminished electrographic spiking, it precipitated electrographic seizure activity similar to that observed following intraperitoneal morphine alone. These seizures were accompanied by behavioral convulsions. No tolerance to these seizures developed with repeated paired administration of morphine and naltrexone or in morphine tolerant rats, but rather potentiation was observed. The epileptogenic effects were found to be potentiated in amygdaloid kindled rats, as well. It was concluded that morphine at these doses activates two different epileptogenic mechanisms, one mediated by opiate receptors, the other not. The possibility of the simultaneous activation of a morphine sensitive anticonvulsant mechanism is discussed.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalBrain Research
Issue number1-2
StatePublished - 16 Dec 1982


  • convulsion
  • electrographic seizures
  • kindling
  • morphine
  • naltrexone


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