TY - JOUR
T1 - Opening of K(ATP) channels is mandatory for acquisition of ischemic tolerance by adenosine
AU - Reshef, Ayelet
AU - Sperling, Oded
AU - Zoref-Shani, Esther
PY - 2000
Y1 - 2000
N2 - Binding of adenosine to neuronal adenosine receptors activates a signal transduction pathway (the adenosine mechanism), leading to a temporary ischemic tolerance. We have demonstrated before the induction of this mechanism in primary rat neuronal cultures, by activation of adenosine receptors, or by activation of protein kinase C (PKC), confers a wide time window of ischemic tolerance, lasting up to 72h, the early (immediate) part of which depends on opening of K(ATP) channels (glibenclamide sensitive). Here we demonstrate that the entire duration of the ischemic tolerance conferred by activation of the adenosine mechanism depends on opening of the K(ATP) channels. Thus, opening of the K(ATP) channels appears to be a mandatory step in the adenosine mechanism, leading to the creation of the wide time of ischemic tolerance. (C) 2000 Lippincott Williams and Wilkins.
AB - Binding of adenosine to neuronal adenosine receptors activates a signal transduction pathway (the adenosine mechanism), leading to a temporary ischemic tolerance. We have demonstrated before the induction of this mechanism in primary rat neuronal cultures, by activation of adenosine receptors, or by activation of protein kinase C (PKC), confers a wide time window of ischemic tolerance, lasting up to 72h, the early (immediate) part of which depends on opening of K(ATP) channels (glibenclamide sensitive). Here we demonstrate that the entire duration of the ischemic tolerance conferred by activation of the adenosine mechanism depends on opening of the K(ATP) channels. Thus, opening of the K(ATP) channels appears to be a mandatory step in the adenosine mechanism, leading to the creation of the wide time of ischemic tolerance. (C) 2000 Lippincott Williams and Wilkins.
KW - 1,2 Dioctanoyl-rac-glycerol (DOG)
KW - ATP-sensitive potassium (K(ATP)) channels
KW - Adenosine
KW - Cromakalim
KW - Glibenclamide
KW - Ischemic tolerance
KW - N-(R)- phenylisopropyladenosine (R-PIA)
KW - Neuronal cultures
UR - http://www.scopus.com/inward/record.url?scp=0033999771&partnerID=8YFLogxK
U2 - 10.1097/00001756-200002280-00007
DO - 10.1097/00001756-200002280-00007
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AN - SCOPUS:0033999771
SN - 0959-4965
VL - 11
SP - 463
EP - 465
JO - NeuroReport
JF - NeuroReport
IS - 3
ER -