@article{d554c19cfcc74f59890fb59e521b6687,
title = "OpenADAM: an open source genome-wide association data management system for Affymetrix SNP arrays.",
abstract = "BACKGROUND: Large scale genome-wide association studies have become popular since the introduction of high throughput genotyping platforms. Efficient management of the vast array of data generated poses many challenges. DESCRIPTION: We have developed an open source web-based data management system for the large amount of genotype data generated from the Affymetrix GeneChip Mapping Array and Affymetrix Genome-Wide Human SNP Array platforms. The database supports genotype calling using DM, BRLMM, BRLMM-P or Birdseed algorithms provided by the Affymetrix Power Tools. The genotype and corresponding pedigree data are stored in a relational database for efficient downstream data manipulation and analysis, such as calculation of allele and genotype frequencies, sample identity checking, and export of genotype data in various file formats for analysis using commonly-available software. A novel method for genotyping error estimation is implemented using linkage disequilibrium information from the HapMap project. All functionalities are accessible via a web-based user interface. CONCLUSION: OpenADAM provides an open source database system for management of Affymetrix genome-wide association SNP data.",
author = "Yeung, \{J. M.\} and Sham, \{P. C.\} and Chan, \{A. S.\} and Cherny, \{S. S.\}",
note = "Funding Information: Some of this work was done while JMYY was a Research Assistant in our group at the Genome Research Centre and partially supported by The University of Hong Kong's strategic research theme of Genomics, Proteomics and Bio-Informatics. We acknowledge support from grant EY-12562 from the National Insitutes of Health, USA, to PCS and SSC.",
year = "2008",
doi = "10.1186/1471-2164-9-636",
language = "אנגלית",
volume = "9",
pages = "636",
journal = "BMC genomics",
issn = "1471-2164",
}