Open randomized comparison of different itraconazole regimens for the treatment of onychomycosis

A. Shemer, Nir Nathansohn*, B. Kaplan, D. Gilat, N. Newman, H. Trau

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

AIMS: This study aimed to compare the efficacy of four different itraconazole regimens in the treatment of toenail onychomycosis caused by dermatophytes. METHODS: The four treatment regimens were: 3 months and 4 months of continuous treatment (200 mg/day of itraconazole) vs 3 months and 4 months of pulse therapy (400 mg/day of itraconazole for 1 week every month). The follow-up period was for 48 weeks after the end of treatment. RESULTS: A total of 66 patients completed the study. Only three patients (4.5) had reversible abnormal liver function tests. No significant difference in cure rates was noted between the pulse and the continuous treatment regimens during the follow-up period. At 12 and 24 weeks after the end of treatment, more patients in the 4-month treatment groups were cured compared with the 3-month treatment groups. However, at the end of the follow-up period the cure rates levelled among the four different regimens. CONCLUSION: Itraconazole, in each of the regimens tested, proved to be efficient and safe for the long-term treatment of onychomycosis. Because no difference was noted between the four regimens, the shorter and more tolerable 3-month pulse treatment is preferable.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalJournal of Dermatological Treatment
Volume10
Issue number4
DOIs
StatePublished - Dec 1999
Externally publishedYes

Keywords

  • Continuous treatment
  • Itraconazole
  • Onychomycosis
  • Pulse therapy

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