Ontogenic development of the reactivity of macrophages to antigenic stimulation

Britta Hardy*, Amiela Globerson, David Danon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Experiments were performed to test the ability of macrophages from newborn mice to participate in immune reactions. It was found that peritoneal cells from 4-day-old mice injected at birth with thioglycollate did not reconstitute reactivity to Shigella in adult, irradiated mice, while normal adult macrophages did. The total yield of peritoneal exudate cells (PEC) was relatively low, yet the number of precursor cells of macrophages in the newborn spleen was found in significantly higher concentrations than in the adult. The number of precursor cells in the spleens of 0-3-day-old mice did not increase in response to antigenic stimulation, indicating that they too are unable at this stage to develop reactivity to immunological signals.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalCellular Immunology
Issue number2
StatePublished - Nov 1973
Externally publishedYes


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