One year outcome and predictors of treatment outcome in central serous chorioretinopathy: Multimodal imaging based analysis

Supriya Arora, Dmitrii S. Maltsev, Sumit Singh Randhir, Niroj Kumar Sahoo, Mahima Jhingan, Deepika Parmeshwarappa, Tarun Arora, Alexei Kulikov, Claudio Iovino, Dinah Zur, Gilad Fainberg, Mohammed Nasar Ibrahim, Filippo Tatti, Ramkailash Gujar, Ramesh Venkatesh, Nikitha Reddy, Ram Snehith, Enrico Peiretti, Marco Lupidi, Jay Chhablani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate the follow up and treatment outcome of central serous chorioretinopathy (CSCR) based on the new multimodal imaging-based classification and identify the predictors for anatomic and visual outcome. Methods: Retrospective, multicentric study on 95 eyes diagnosed with CSCR and a follow up of at least 12 months were included. Eyes with macular neovascularization, atypical CSCR or any other disease were excluded. Results: At the baseline, observation was advised to 70% eyes with simple CSCR whereas photodynamic therapy (PDT) was performed in 49% eyes with complex CSCR. Over the follow up, decrease in CMT was significantly higher in simple CSCR as compared to complex CSCR (P = 0.008) and the recurrences were significantly more in eyes with lower CMT at baseline (P = 0.0002). Median time of resolution of SRF was 3 months and 6 months in simple and complex CSCR respectively (P = 0.09). For the 12 months follow up, the median fluid free period was greater (P = 0.03) while number of interventions performed was lesser in eyes with simple CSCR as compared to complex CSCR (P = 0.006). Multiple regression analysis showed baseline best corrected visual acuity (BCVA) and baseline persistent SRF to be significantly predictive of BCVA and persistent SRF at 12 months (P < 0.0001, 0.04) respectively. Conclusions: Complex CSCR more often required PDT, was associated with shorter fluid free interval and longer time for SRF resolution. Baseline BCVA and persistent SRF were predictive of final visual and anatomical outcome. The new multimodal imaging based classification is helpful in establishing objective criteria for planning treatment approaches for CSCR.

Original languageEnglish
Pages (from-to)2319-2327
Number of pages9
JournalEuropean Journal of Ophthalmology
Issue number4
StatePublished - Jul 2022


  • CME < retina
  • central serous chorioretinopathy < retina
  • retina – medical therapies < retina
  • retinal pathology/research < retina
  • techniques of retinal examination < retina


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