One-pot synthesis of glucosamine oligosaccharides

Micha Fridman, Dmitry Solomon, Shay Yogev, Timor Baasov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chemical equation presented Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synthesis in a one-pot manner. One-pot sequential glycosylation of three and four units of 2-amino-2-deoxy glucose gave trisaccharides and tetrasaccharide in 50-81% yields.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalOrganic Letters
Volume4
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

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