Oncologic outcomes following robot-assisted radical prostatectomy for clinical T3 prostate disease

Dorit E. Zilberman*, Yasmin Abu-Ghanem, Gil Raviv, Barak Rosenzweig, Eddie Fridman, Orith Portnoy, A Dotan Zohar A Dotan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Little is known about oncologic outcomes following robot-assisted-radical-prostatectomy (RALP) for clinical T3 (cT3) prostate cancer. Objectives: To investigate oncologic outcomes of patients with cT3 prostate cancer treated by RALP. Methods: Medical records of patients who underwent RALP from 2010 to 2018 were retrieved. cT3 cases were reviewed. Demographic and pre/postoperative pathology data were analyzed. Patients were followed in 3-6 month intervals with repeat PSA analyses. Adjuvant/salvage treatments were monitored. Biochemical recurrence (BCR) meant PSA levels of ≥ 0.2 ng/ml. Results: Seventy-nine patients met inclusion criteria. Median age at surgery was 64 years. Preoperative PSA level was 7.14 ng/dl, median prostate weight was 54 grams, and 23 cases (29.1%) were down-staged to pathological stage T2. Positive surgical margin rate was 42%. Five patients were lost to follow-up. Median follow-up time for the remaining 74 patients was 24 months. Postoperative relapse in PSA levels occurred in 31 patients (42%), and BCR in 28 (38%). Median time to BCR was 9 months. The overall 5-year BCR-free survival rate was 61%. Predicting factors for BCR were age (hazard-ratio [HR] 0.85,95%confidence interval [95%CI] 0.74-0.97, P= 0.017) and prostate weight (HR 1.04, 95%CI 1.01-1.08, P= 0.021). Twenty-six patients (35%) received adjuvant/salvage treatments. Three patients died from metastatic prostate cancer 31, 52, and 78 months post-surgery. Another patient died 6 months post-surgery of unknown reasons. The 5-year cancer-specific survival rate was 92%. Conclusions: RALP is an oncologic effective procedure for cT3 prostate cancer. Adjuvant/salvage treatment is needed to achieve optimal disease-control.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalIsrael Medical Association Journal
Issue number2
StatePublished - Feb 2021


  • Clinical T3
  • Oncologic outcomes
  • Prostate cancer
  • Robot-assisted radical prostatectomy


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