Oncogenic Viruses and Hepatocellular Carcinoma

Ziv Ben Ari; Ella Weitzman; Michal Safran

doi:10.1016/j.cld.2015.01.006

Oncogenic Viruses and Hepatocellular Carcinoma

Ziv Ben Ari^*, Ella Weitzman, Michal Safran

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

About 80% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HCC prevention a major goal of antiviral therapy. HCC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in promoting HCC development are still either directly or indirectly are still speculative, but the evidence for both effects is compelling. In patients with chronic hepatitis viral infection, cirrhosis is not a prerequisite for tumorigenesis.

Original language	English
Pages (from-to)	341-360
Number of pages	20
Journal	Clinics in Liver Disease
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.cld.2015.01.006
State	Published - 1 May 2015

Keywords

Hepatitis B
Hepatitis C
Hepatocellular carcinoma
Oncogenic viruses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cld.2015.01.006

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title = "Oncogenic Viruses and Hepatocellular Carcinoma",

abstract = "About 80% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HCC prevention a major goal of antiviral therapy. HCC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in promoting HCC development are still either directly or indirectly are still speculative, but the evidence for both effects is compelling. In patients with chronic hepatitis viral infection, cirrhosis is not a prerequisite for tumorigenesis.",

keywords = "Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Oncogenic viruses",

author = "{Ben Ari}, Ziv and Ella Weitzman and Michal Safran",

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doi = "10.1016/j.cld.2015.01.006",

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T1 - Oncogenic Viruses and Hepatocellular Carcinoma

AU - Ben Ari, Ziv

AU - Weitzman, Ella

AU - Safran, Michal

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Y1 - 2015/5/1

N2 - About 80% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HCC prevention a major goal of antiviral therapy. HCC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in promoting HCC development are still either directly or indirectly are still speculative, but the evidence for both effects is compelling. In patients with chronic hepatitis viral infection, cirrhosis is not a prerequisite for tumorigenesis.

AB - About 80% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HCC prevention a major goal of antiviral therapy. HCC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in promoting HCC development are still either directly or indirectly are still speculative, but the evidence for both effects is compelling. In patients with chronic hepatitis viral infection, cirrhosis is not a prerequisite for tumorigenesis.

KW - Hepatitis B

KW - Hepatitis C

KW - Hepatocellular carcinoma

KW - Oncogenic viruses

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JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 2

ER -

Oncogenic Viruses and Hepatocellular Carcinoma

Abstract

Keywords

UN SDGs

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