On the possible schistosomulicidal effect of macrophage-derived lysozyme

E. Flescher, Y. Keisari, J. Lengy, D. Gold

Research output: Contribution to journalArticlepeer-review


Lysozyme secretion from macrophages of Schistosoma mansoni-infected mice was time dependent, rising significantly from the 8th week post-infection, the macrophages thereafter exhibiting very high levels (> 90%) of schistosomulicidal activity. Despite the ability of lysozyme to kill schistosomula in vitro, the concentrations required for such killing were several hundred-fold to several thousand-fold higher than those detected in the supernatants from infected-mice macrophages cultured with or without schistosomula. An in vitro lysozyme inhibitor, N,N,N-triacetyl chitobiose, did not abrogate the cytotoxic ability of macrophages from schistosome-infected mice, but an inhibitor of arginine-dependent cytotoxicity, NG-monomethyl arginine, markedly inhibited schistosomulicidal activity. Evidently, concentrations of ambient lysozyme from macrophage cultures are too low to affect schistosomula in culture, while the main schistosomulicidal pathway in vitro seems to be arginine dependent.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
Issue number1
StatePublished - 1991


  • Schistosoma mansoni
  • arginine
  • lysozyme
  • macrophages
  • schistosomula


Dive into the research topics of 'On the possible schistosomulicidal effect of macrophage-derived lysozyme'. Together they form a unique fingerprint.

Cite this