On the opioid nature of phencyclidine and its 3-hydroxy derivative

Yossef Itzhak; Asher Kalir; Yosef Sarne

doi:10.1016/0014-2999(81)90097-2

On the opioid nature of phencyclidine and its 3-hydroxy derivative

Yossef Itzhak^*
, Asher Kalir
, Yosef Sarne

^*Corresponding author for this work

Physiology Pharmacology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [³H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [³H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	European Journal of Pharmacology
Volume	73
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(81)90097-2
State	Published - 17 Jul 1981

Keywords

Opioid agonistic-antagonistic effect
Opioid receptors
Phencyclidine (PCP)

Access to Document

10.1016/0014-2999(81)90097-2

Cite this

@article{224709ebe583429b9311cb803de8ce90,

title = "On the opioid nature of phencyclidine and its 3-hydroxy derivative",

abstract = "Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.",

keywords = "Opioid agonistic-antagonistic effect, Opioid receptors, Phencyclidine (PCP)",

author = "Yossef Itzhak and Asher Kalir and Yosef Sarne",

year = "1981",

month = jul,

day = "17",

doi = "10.1016/0014-2999(81)90097-2",

language = "אנגלית",

volume = "73",

pages = "229--233",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - On the opioid nature of phencyclidine and its 3-hydroxy derivative

AU - Itzhak, Yossef

AU - Kalir, Asher

AU - Sarne, Yosef

PY - 1981/7/17

Y1 - 1981/7/17

N2 - Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.

AB - Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.

KW - Opioid agonistic-antagonistic effect

KW - Opioid receptors

KW - Phencyclidine (PCP)

UR - https://www.scopus.com/pages/publications/0019827613

U2 - 10.1016/0014-2999(81)90097-2

DO - 10.1016/0014-2999(81)90097-2

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0019827613

SN - 0014-2999

VL - 73

SP - 229

EP - 233

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

On the opioid nature of phencyclidine and its 3-hydroxy derivative

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this