TY - JOUR
T1 - On the opioid nature of phencyclidine and its 3-hydroxy derivative
AU - Itzhak, Yossef
AU - Kalir, Asher
AU - Sarne, Yosef
PY - 1981/7/17
Y1 - 1981/7/17
N2 - Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.
AB - Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.
KW - Opioid agonistic-antagonistic effect
KW - Opioid receptors
KW - Phencyclidine (PCP)
UR - http://www.scopus.com/inward/record.url?scp=0019827613&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(81)90097-2
DO - 10.1016/0014-2999(81)90097-2
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AN - SCOPUS:0019827613
SN - 0014-2999
VL - 73
SP - 229
EP - 233
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -