On the opioid nature of phencyclidine and its 3-hydroxy derivative

Yossef Itzhak*, Asher Kalir, Yosef Sarne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - 17 Jul 1981


  • Opioid agonistic-antagonistic effect
  • Opioid receptors
  • Phencyclidine (PCP)


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