On the combined effect of statins and lycopene on cytokine production by human peripheral blood cells

Michael Bergman, Meir Djaldetti*, Hertzel Salman, Hanna Bessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Since both statins and lycopene exert immunomodulatory activities following incubation with human peripheral blood mononuclear cells (PBMC), the present work was designed to examine whether they may induce a synergistic or antagonistic effect on cytokine production while applied together. Peripheral blood mononuclear cells isolated from 15 healthy subjects were incubated for 24 h as follows: (1) without and with 0.125 or 0.25 μM lycopene, (2) without and with 10 or 50 mM pravastatin or simvastatin, and (3) with lycopene and with one of the statins together at the respective doses. The production of the following cytokines was assessed: interleukin (IL)-1β, IL-1ra, IL-2, and IL-10, as well as tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ). The results showed that lycopene and simvastatin applied together reduced TNFα and IFNγ secretion, and abolished the increased production of the proinflammatory cytokine IL-1γ caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses.

Original languageEnglish
Pages (from-to)426-431
Number of pages6
JournalHeart and Vessels
Volume25
Issue number5
DOIs
StatePublished - Sep 2010

Keywords

  • Cytokine
  • Human mononuclear cells
  • Lycopene
  • Pravastatin
  • Simvastatin

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