On the Chemistry of Latrunculins A and B

Dina Blasberger, Shmuel Carmely, Yoel Kashman, Miriam Cojocaru, Ilan Spector, Nava R. Shochet

Research output: Contribution to journalArticlepeer-review

Abstract

The chemical behavior of latrunculins A (1) and B (2) (Lat A and B) under a variety of reaction conditions is described. The combination of the macrolide, the THP‐lactol, and the 2‐thiazolidinone rings was found to result in interesting unpredicted chemical transformations. The structures of two new Lats, 6,7‐epoxy‐Lat A (3) and Lat M (4) isolated from Latrunculia magnifica are discussed.

Original languageEnglish
Pages (from-to)1171-1188
Number of pages18
JournalLiebigs Annalen der Chemie
Volume1989
Issue number12
DOIs
StatePublished - 1989

Keywords

  • Actin
  • Latrunculins

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