TY - GEN
T1 - ON-DEMAND PERM-SELECTIVE MEDIUM USING MICROVALVES FOR IONIC CONCENTRATION-POLARIZATION-BASED PRECONCENRATION
AU - Sabbagh, Barak
AU - Park, Sinwook
AU - Yossifon, Gilad
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Microfluidic channels containing an ionic permselective medium (e.g. porous membrane) are commonly used for biomolecule preconcentration for enhanced biosensing. Herein, we show the ability to dynamically activate/deactivate a perm-selective medium by integrating individually addressable microvalves and a uniformly coated membrane film within a microchannel. We demonstrated that the interplay of bulk-membrane ionic transport can be controlled by activating the microvalve and enables a dynamic control on the developed concentration-polarization and associated preconcentrated molecule plug. This ability introduces a robust and simple way to implement a variety of functionalities into lab-on-a-chip devices, e.g. sensitive multiplex sensing, fouling prevention, and steric filtration.
AB - Microfluidic channels containing an ionic permselective medium (e.g. porous membrane) are commonly used for biomolecule preconcentration for enhanced biosensing. Herein, we show the ability to dynamically activate/deactivate a perm-selective medium by integrating individually addressable microvalves and a uniformly coated membrane film within a microchannel. We demonstrated that the interplay of bulk-membrane ionic transport can be controlled by activating the microvalve and enables a dynamic control on the developed concentration-polarization and associated preconcentrated molecule plug. This ability introduces a robust and simple way to implement a variety of functionalities into lab-on-a-chip devices, e.g. sensitive multiplex sensing, fouling prevention, and steric filtration.
KW - Concentration-polarization
KW - Ion perm-selective
KW - Microvalve
KW - Preconcentration
UR - http://www.scopus.com/inward/record.url?scp=85136996857&partnerID=8YFLogxK
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AN - SCOPUS:85136996857
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 19
EP - 20
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -