Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022

Nofar Atari; Limor Kliker; Neta Zuckerman; Bayan Abd Elkader; Yael Weiss-Ottolenghi; Ella Mendelson; Yitshak Kreiss; Gili Regev-Yochay; Michal Mandelboim

doi:10.2807/1560-7917.ES.2022.27.44.2200785

Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022

Nofar Atari, Limor Kliker, Neta Zuckerman, Bayan Abd Elkader, Yael Weiss-Ottolenghi, Ella Mendelson, Yitshak Kreiss, Gili Regev-Yochay, Michal Mandelboim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in vaccinated individuals resulted in increased neutralising antibodies against the WT and Omicron variants compared with vaccinated uninfected HCW. HCW who recovered from BA.1 or BA.5 infections showed similar neutralising antibodies levels against BA.2.75.

Original language	English
Journal	Eurosurveillance
Volume	27
Issue number	44
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.44.2200785
State	Published - 3 Nov 2022

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10.2807/1560-7917.ES.2022.27.44.2200785

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Atari, N., Kliker, L., Zuckerman, N., Elkader, B. A., Weiss-Ottolenghi, Y., Mendelson, E., Kreiss, Y., Regev-Yochay, G., & Mandelboim, M. (2022). Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022. Eurosurveillance, 27(44). https://doi.org/10.2807/1560-7917.ES.2022.27.44.2200785

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abstract = "We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in vaccinated individuals resulted in increased neutralising antibodies against the WT and Omicron variants compared with vaccinated uninfected HCW. HCW who recovered from BA.1 or BA.5 infections showed similar neutralising antibodies levels against BA.2.75.",

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Atari, N, Kliker, L, Zuckerman, N, Elkader, BA, Weiss-Ottolenghi, Y, Mendelson, E , Kreiss, Y , Regev-Yochay, G & Mandelboim, M 2022, 'Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022', Eurosurveillance, vol. 27, no. 44. https://doi.org/10.2807/1560-7917.ES.2022.27.44.2200785

TY - JOUR

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AU - Atari, Nofar

AU - Kliker, Limor

AU - Zuckerman, Neta

AU - Elkader, Bayan Abd

AU - Weiss-Ottolenghi, Yael

AU - Mendelson, Ella

AU - Kreiss, Yitshak

AU - Regev-Yochay, Gili

AU - Mandelboim, Michal

PY - 2022/11/3

Y1 - 2022/11/3

N2 - We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in vaccinated individuals resulted in increased neutralising antibodies against the WT and Omicron variants compared with vaccinated uninfected HCW. HCW who recovered from BA.1 or BA.5 infections showed similar neutralising antibodies levels against BA.2.75.

AB - We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in vaccinated individuals resulted in increased neutralising antibodies against the WT and Omicron variants compared with vaccinated uninfected HCW. HCW who recovered from BA.1 or BA.5 infections showed similar neutralising antibodies levels against BA.2.75.

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Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022

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