Omeprazole has no effect on acetaminophen kinetics in the rat

E. Melzer; A. Lang; A. Gopher; S. Almog; D. Ezra; S. Bar-Meir

doi:10.1007/BF03226366

Omeprazole has no effect on acetaminophen kinetics in the rat

E. Melzer, A. Lang, A. Gopher, S. Almog, D. Ezra, S. Bar-Meir^*

^*Corresponding author for this work

Clinical Departments

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Abstract

We investigated in the rat the effect of the H⁺/K⁺-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	20
Issue number	2
DOIs	https://doi.org/10.1007/BF03226366
State	Published - Jun 1995

Keywords

Omeprazole
acetaminophen
cytochrome P450

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10.1007/BF03226366

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abstract = "We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.",

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author = "E. Melzer and A. Lang and A. Gopher and S. Almog and D. Ezra and S. Bar-Meir",

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AU - Melzer, E.

AU - Lang, A.

AU - Gopher, A.

AU - Almog, S.

AU - Ezra, D.

AU - Bar-Meir, S.

PY - 1995/6

Y1 - 1995/6

N2 - We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.

AB - We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.

KW - Omeprazole

KW - acetaminophen

KW - cytochrome P450

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JO - European Journal of Drug Metabolism and Pharmacokinetics

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Omeprazole has no effect on acetaminophen kinetics in the rat

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Keywords

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