TY - JOUR
T1 - Omeprazole has no effect on acetaminophen kinetics in the rat
AU - Melzer, E.
AU - Lang, A.
AU - Gopher, A.
AU - Almog, S.
AU - Ezra, D.
AU - Bar-Meir, S.
PY - 1995/6
Y1 - 1995/6
N2 - We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.
AB - We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.
KW - Omeprazole
KW - acetaminophen
KW - cytochrome P450
UR - http://www.scopus.com/inward/record.url?scp=0029121323&partnerID=8YFLogxK
U2 - 10.1007/BF03226366
DO - 10.1007/BF03226366
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AN - SCOPUS:0029121323
SN - 0378-7966
VL - 20
SP - 125
EP - 128
JO - European Journal of Drug Metabolism and Pharmacokinetics
JF - European Journal of Drug Metabolism and Pharmacokinetics
IS - 2
ER -