Omeprazole has no effect on acetaminophen kinetics in the rat

E. Melzer, A. Lang, A. Gopher, S. Almog, D. Ezra, S. Bar-Meir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Issue number2
StatePublished - Jun 1995


  • Omeprazole
  • acetaminophen
  • cytochrome P450


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