Oligomeric interactions of TGF-β and BMP receptors

Marcelo Ehrlich, Orit Gutman, Petra Knaus, Yoav I. Henis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) cytokines participate in a multiplicity of ways in the regulation of numerous physiological and pathological processes. Their wide-ranging biological functions are controlled by several mechanisms, including regulation of transcription, complex formation among the signaling receptors (oligomerization) and with co-receptors, binding of the receptors to scaffolding proteins or their targeting to specific membrane domains. Here, we address the generation of TGF-β and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines. We examine the available biochemical, biophysical and structural evidence for the ternary structure of these complexes, and the possible roles of homomeric and heteromeric receptor oligomers in signaling.

Original languageEnglish
Pages (from-to)1885-1896
Number of pages12
JournalFEBS Letters
Volume586
Issue number14
DOIs
StatePublished - 4 Jul 2012

Funding

FundersFunder number
Israel Cancer Research Fund
Deutsche ForschungsgemeinschaftDFG–SFB 760
German-Israeli Foundation for Scientific Research and Development932-244.13/2006
Israel Science Foundation158/09, 1529/11

    Keywords

    • BMP
    • Oligomerization
    • Receptor
    • Signaling
    • TGF-β

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