@article{471e3daa970743a785d8e84a5ab14da6,
title = "Oligomeric interactions of TGF-β and BMP receptors",
abstract = "Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) cytokines participate in a multiplicity of ways in the regulation of numerous physiological and pathological processes. Their wide-ranging biological functions are controlled by several mechanisms, including regulation of transcription, complex formation among the signaling receptors (oligomerization) and with co-receptors, binding of the receptors to scaffolding proteins or their targeting to specific membrane domains. Here, we address the generation of TGF-β and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines. We examine the available biochemical, biophysical and structural evidence for the ternary structure of these complexes, and the possible roles of homomeric and heteromeric receptor oligomers in signaling.",
keywords = "BMP, Oligomerization, Receptor, Signaling, TGF-β",
author = "Marcelo Ehrlich and Orit Gutman and Petra Knaus and Henis, {Yoav I.}",
note = "Funding Information: We thank Daniel Horbelt for help in preparing the figures. Work in the authors{\textquoteright} laboratories was supported in part by grants from the Israel Science Foundation (Grant 158/09 to Y.I.H., and 1529/11 to M.E.), the Israel Cancer Research Fund (to Y.I.H.), the German-Israeli Foundation for Scientific Research and Development (GIF, Grant 932-244.13/2006, to Y.I.H. and P.K.), and the Deutsche Forschungsgemeinschaft (grant DFG–SFB 760, to P.K.). Y.I.H. is the incumbent of the Zalman Weinberg Chair in Cell Biology.",
year = "2012",
month = jul,
day = "4",
doi = "10.1016/j.febslet.2012.01.040",
language = "אנגלית",
volume = "586",
pages = "1885--1896",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley-Blackwell",
number = "14",
}