Olfactory sensitivity in major depressive disorder and obsessive compulsive disorder

Ruth Gross-Isseroff*, Keren Luca-Haimovici, Yehuda Sasson, Seth Kindler, Moshe Kotler, Joseph Zohar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Olfactory sensitivity to two odorants, isoamyl acetate and androstenone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of antidepressant drug therapy. No difference in olfactory sensitivity, to either odorant, was found between OCD patientsand controls at any time. In MDD patients, a significant increase in the sensitivity to isoamyl acetate was observed 6 weeks after initiation of treatment, compared to controls.

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalBiological Psychiatry
Issue number10
StatePublished - 15 May 1994
Externally publishedYes


  • Olfactory thresholds, obsessive compulsive disorder
  • androstenone
  • isoamyl acetate
  • major depressive disorder


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