Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis

Maya Koren-Michowitz*, Aiko Sato-Otsubo, Arnon Nagler, Torsten Haferlach, Seishi Ogawa, H. Phillip Koeffler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (<60 years old) and old (≥60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p= 0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p= 0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.

Original languageEnglish
Pages (from-to)467-473
Number of pages7
JournalLeukemia Research
Volume36
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Funding

FundersFunder number
Inger Fund
Parker Hughes TrustNSFC30470980
National Institutes of Health5R01CA026038-31
National Center for Advancing Translational SciencesUL1TR000124
Agency for Science, Technology and Research

    Keywords

    • AML
    • Normal karyotype
    • Old age
    • SNP array

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