Abstract
Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (<60 years old) and old (≥60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p= 0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p= 0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.
Original language | English |
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Pages (from-to) | 467-473 |
Number of pages | 7 |
Journal | Leukemia Research |
Volume | 36 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2012 |
Externally published | Yes |
Keywords
- AML
- Normal karyotype
- Old age
- SNP array