@article{a6a50a2fdd4943fdbf8159fb01db1d44,
title = "Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis",
abstract = "Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (<60 years old) and old (≥60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p= 0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p= 0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.",
keywords = "AML, Normal karyotype, Old age, SNP array",
author = "Maya Koren-Michowitz and Aiko Sato-Otsubo and Arnon Nagler and Torsten Haferlach and Seishi Ogawa and Koeffler, {H. Phillip}",
note = "Funding Information: Presence of CNN-LOH was supported by sequencing random SNPs selected from within the area of CNN-LOH in chromosome 1p (case #43) and demonstrating LOH compared to random SNP sequences outside of the CNN-LOH area demonstrating heterozygous SNP calls. Gene dosage of chromosome 11q (case #14) was determined using real time quantitative (RQ) PCR in order to support allelic loss, as previously described [9,10] . ",
year = "2012",
month = apr,
doi = "10.1016/j.leukres.2011.10.013",
language = "אנגלית",
volume = "36",
pages = "467--473",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Ltd.",
number = "4",
}
