Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis

Maya Koren-Michowitz; Aiko Sato-Otsubo; Arnon Nagler; Torsten Haferlach; Seishi Ogawa; H. Phillip Koeffler

doi:10.1016/j.leukres.2011.10.013

Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis

Maya Koren-Michowitz^*, Aiko Sato-Otsubo, Arnon Nagler, Torsten Haferlach, Seishi Ogawa, H. Phillip Koeffler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (<60 years old) and old (≥60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p= 0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p= 0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.

Original language	English
Pages (from-to)	467-473
Number of pages	7
Journal	Leukemia Research
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2011.10.013
State	Published - Apr 2012
Externally published	Yes

Keywords

AML
Normal karyotype
Old age
SNP array

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2011.10.013

Cite this

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title = "Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis",

abstract = "Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (<60 years old) and old (≥60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p= 0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p= 0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.",

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author = "Maya Koren-Michowitz and Aiko Sato-Otsubo and Arnon Nagler and Torsten Haferlach and Seishi Ogawa and Koeffler, {H. Phillip}",

note = "Funding Information: Presence of CNN-LOH was supported by sequencing random SNPs selected from within the area of CNN-LOH in chromosome 1p (case #43) and demonstrating LOH compared to random SNP sequences outside of the CNN-LOH area demonstrating heterozygous SNP calls. Gene dosage of chromosome 11q (case #14) was determined using real time quantitative (RQ) PCR in order to support allelic loss, as previously described [9,10] . ",

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doi = "10.1016/j.leukres.2011.10.013",

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AU - Koren-Michowitz, Maya

AU - Sato-Otsubo, Aiko

AU - Nagler, Arnon

AU - Haferlach, Torsten

AU - Ogawa, Seishi

AU - Koeffler, H. Phillip

N1 - Funding Information: Presence of CNN-LOH was supported by sequencing random SNPs selected from within the area of CNN-LOH in chromosome 1p (case #43) and demonstrating LOH compared to random SNP sequences outside of the CNN-LOH area demonstrating heterozygous SNP calls. Gene dosage of chromosome 11q (case #14) was determined using real time quantitative (RQ) PCR in order to support allelic loss, as previously described [9,10] .

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AB - Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (<60 years old) and old (≥60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p= 0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p= 0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.

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KW - Normal karyotype

KW - Old age

KW - SNP array

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Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis

Abstract

Keywords

UN SDGs

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