TY - JOUR
T1 - Older age is risk for an International Normalized Ratio (INR) of 5 or more
AU - Ribak, G.
AU - Barak, M.
AU - Froom, Paul
PY - 2007
Y1 - 2007
N2 - The elderly have higher INR values, but this may be due to factors such as inter-current illnesses or drug changes. In the following case-controlled study we contacted 304 patients receiving warfarin treatment, one group with an INR of 5 or more, and three control groups (INR < 2, 2-3.9, 4-4.9). Variables that significantly predicted an INR of 5 or more in a logistic regression model included age, the use of antibiotics, stopping of a chronic drug, and the lack of knowledge of the target INR. After forcing in other variables associated with age (less valve disease, more use of multivitamins, and a lower dose of warfarin) the increased risk was 1.6 (1.12-2.28) per 10 years of age. We conclude that age is an independent risk factor for INR values of 5 or or more.
AB - The elderly have higher INR values, but this may be due to factors such as inter-current illnesses or drug changes. In the following case-controlled study we contacted 304 patients receiving warfarin treatment, one group with an INR of 5 or more, and three control groups (INR < 2, 2-3.9, 4-4.9). Variables that significantly predicted an INR of 5 or more in a logistic regression model included age, the use of antibiotics, stopping of a chronic drug, and the lack of knowledge of the target INR. After forcing in other variables associated with age (less valve disease, more use of multivitamins, and a lower dose of warfarin) the increased risk was 1.6 (1.12-2.28) per 10 years of age. We conclude that age is an independent risk factor for INR values of 5 or or more.
KW - Elderly
KW - INR
KW - Oral anticoagulation
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=38649119818&partnerID=8YFLogxK
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AN - SCOPUS:38649119818
SN - 1433-6510
VL - 53
SP - 571
EP - 574
JO - Clinical Laboratory
JF - Clinical Laboratory
IS - 11-12
ER -